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Patients with severe renal impairment who took vidagliptin displayed a higher rate of infections and infestations than patients taking placebo.
The drug combination that seems most logical is incretin-based therapies (addressing 4 out of the 8 pathophysiological mechanisms) with biguanide (metformin) or TZD (addressing insulin resistance at liver and skeletal muscle).
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However, unlike exenatide, which is given by injection, DPP-4 inhibitor drugs are taken as pills by mouth.
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Most importantly, these results achieved at 12 weeks were sustained over a year, indicating that patients treated with Galvus can achieve good long-term sugar control.
Onglyza was approved for the treatment of the symptoms of type-2 diabetes.
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In the wake of the defeat of the XIVth Legion and Gaius Van Belsar and the start of the 7th Astral Era, the truce for the sake of unity between the two political factions came to a quiet end, with the Monetarists seeking to gain more power and wealth, while taking power away from Nanamo and her supporters, including Raubahn.
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All this has already been accomplished by the original manufacturer, and was subsequently reflected in the brand-name drug price.
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Like sulfonylureas, these medicines help the pancreas produce more insulin.
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In October 2006, the FDA approved the first DPP-4 inhibitor.
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These studies have shown that administration of insulin, IGF-1 and GLP-1 agonists reverses signaling abnormalities and has positive effects on surrogate markers of neurodegeneration and behavioral outcomes.
So as a result, as you can see from the chart, this gives you some directional idea where we expect the Galvus franchise to end up in around 2018.
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No secretagogue of L cells has been specifically developed, though clear headway has been made in elucidating how food products bring about GLP-1 secretion from L cells (Fig.
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