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The minimal effective dose for maintenance therapy should be determined by titration.

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Osphena (ospemifene) was approved a year ago for postmenopausal women suffering from painful intercourse.

The reported endometrial cancer risk among unopposed estrogen users is about 2- to 12-fold greater than in non-users, and appears dependent on duration of treatment and on estrogen dose.

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Estradiol then binds to HSP and can (form structures of two HSP and two estradiol molecules) and then bind to specific domains on the nucleus (, ERE), allowing for gene transcription which can take place over hours and days.

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