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Given these challenges, some experts have argued that the role of rifamycins in treating TB is so important that deferral of HAART should be considered until completion of TB therapy ( CIII).

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Patients who develop IRIS related to cryptococcosis are more likely than those who do not develop cyrptococcal IRIS to be severely immunocompromised with disseminated infection and to have initiated potent antiretroviral therapy soon after diagnosis of cryptococcal disease ( 370); in antiretroviral-naïve patients newly diagnosed with cryptococcal meningitis, delay in potent antiretroviral therapy may be prudent until the end of the first 2 weeks of induction therapy ( CIII).

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